SCOP 1.73: Domain d1e2kb_: 1e2k B:

Lineage for d1e2kb_ (1e2k B:)

1. Root: SCOP 1.73

2. Class c: Alpha and beta proteins (a/b) [51349] (141 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (24 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (20 proteins)
   parallel beta-sheet of 5 strands, order 23145

6. Protein Thymidine kinase [52552] (3 species)
   contains insert all-alpha subdomain, res. 251-322

7. Species Herpes simplex virus type 1, different strains [TaxId:10298] [52553] (22 PDB entries)

8. Domain d1e2kb_: 1e2k B: [31855]
   complexed with so4, tmc; mutant

Details for d1e2kb_

PDB Entry: 1e2k, 1.7 Å

PDB Description: kinetics and crystal structure of the wild-type and the engineered y101f mutant of herpes simplex virus type 1 thymidine kinase interacting with (north)-methanocarba-thymidine

PDB Compounds: (B:) Thymidine kinase

SCOP Domain Sequences for d1e2kb_:

Sequence, based on SEQRES records:

>d1e2kb_ c.37.1.1 (B:) Thymidine kinase {Herpes simplex virus type 1, different strains [TaxId: 10298]}
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrhp
iaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpge
rldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphig
dtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlts
gmvqthvttpgsipticdlartfaremge

Sequence, based on observed residues (ATOM records):

>d1e2kb_ c.37.1.1 (B:) Thymidine kinase {Herpes simplex virus type 1, different strains [TaxId: 10298]}
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeahapppaltlifdrhpiaa
llcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrerldlaml
aairrvygllantvrylqcggswredwgqlsgtavpqsnagprphigdtlftlfrapell
apngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsi
pticdlartfaremge

Timeline for d1e2kb_:

• d1e2kb_ first appeared (with stable ids) in SCOP 1.55
  
• d1e2kb_ appears in SCOP 1.71
  
• d1e2kb_ appears in SCOP 1.75
  
• d1e2kb_ appears in the current release, SCOPe 2.08