SCOPe 2.08: Domain d5dsxa_: 5dsx A:

Lineage for d5dsxa_ (5dsx A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (61 families)

5. Family c.66.1.31: Catalytic, N-terminal domain of histone methyltransferase Dot1l [89746] (2 proteins)

6. Protein automated matches [191247] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189737] (31 PDB entries)

8. Domain d5dsxa_: 5dsx A: [318371]
   automated match to d4hraa_
   complexed with 5ew, k

Details for d5dsxa_

PDB Entry: 5dsx, 2.41 Å

PDB Description: crystal structure of dot1l in complex with inhibitor cpd10 [6'-chloro- 1,4-dimethyl-5'-(2-methyl-6-((4-(methylamino)pyrimidin-2-yl)amino)- 1h-indol-1-yl)-[3,3'-bipyridin]-2(1h)-one]

PDB Compounds: (A:) Histone-lysine N-methyltransferase, H3 lysine-79 specific

SCOPe Domain Sequences for d5dsxa_:

Sequence, based on SEQRES records:

>d5dsxa_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpek
lnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhyg
vekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfa
fgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgsvs
wtgkpvsyylhtidrtilenyfsslknp

Sequence, based on observed residues (ATOM records):

>d5dsxa_ c.66.1.31 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgtntrpstgllrhilqqvynhsvtdpeklepfsp
evygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvekadipak
yaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpevdhql
kerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkswtgkpvsyylht
idrtilenyfsslknp

Timeline for d5dsxa_:

• d5dsxa_ first appeared in SCOPe 2.06
  
• d5dsxa_ appears in SCOPe 2.07