SCOPe 2.08: Domain d5bwza1: 5bwz A:14-377

Lineage for d5bwza1 (5bwz A:14-377)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.42: Arginase/deacetylase [52767] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456

4. Superfamily c.42.1: Arginase/deacetylase [52768] (3 families)

5. Family c.42.1.2: Histone deacetylase, HDAC [52773] (4 proteins)
   automatically mapped to Pfam PF00850

6. Protein automated matches [190786] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188039] (41 PDB entries)

8. Domain d5bwza1: 5bwz A:14-377 [318073]
   Other proteins in same PDB: d5bwza2
   automated match to d2v5wb_
   complexed with gol, k, xch, zn

Details for d5bwza1

PDB Entry: 5bwz, 1.59 Å

PDB Description: crystal structure of s39e hdac8 in complex with droxinostat

PDB Compounds: (A:) Histone deacetylase 8

SCOPe Domain Sequences for d5bwza1:

Sequence, based on SEQRES records:

>d5bwza1 c.42.1.2 (A:14-377) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lvpvyiyspeyvsmcdslakipkraemvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggatitaaqclidgmckv
ainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsfts
kvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyq
afnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantar
cwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnl
khvv

Sequence, based on observed residues (ATOM records):

>d5bwza1 c.42.1.2 (A:14-377) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lvpvyiyspeyvsmcdslakipkraemvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqehpdsieyglgydcpategifdyaaaiggatitaaqclidgmckvainw
sggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmt
vslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnp
kavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantarcwty
ltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvv

Timeline for d5bwza1:

• d5bwza1 first appeared in SCOPe 2.06
  
• d5bwza1 appears in SCOPe 2.07