SCOPe 2.06: Domain d5i6vb3: 5i6v B:219-525

Lineage for d5i6vb3 (5i6v B:219-525)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (7 proteins)
   has an extension to the beta-sheet of 3 antiparallel strands before strand 4

6. Protein automated matches [190252] (3 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187034] (28 PDB entries)

8. Domain d5i6vb3: 5i6v B:219-525 [315542]
   Other proteins in same PDB: d5i6va1, d5i6va2, d5i6vb1, d5i6vb2
   automated match to d2shpa1
   complexed with gol; mutant

Details for d5i6vb3

PDB Entry: 5i6v, 1.87 Å

PDB Description: structure of f285s, a cancer-associated mutation of the oncogenic phosphatase shp2

PDB Compounds: (B:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d5i6vb3:

Sequence, based on SEQRES records:

>d5i6vb3 c.45.1.2 (B:219-525) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpsdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymav
qhyietl

Sequence, based on observed residues (ATOM records):

>d5i6vb3 c.45.1.2 (B:219-525) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelskgfweefetlqqqeckllysrkegqrqenknknryknilpsdht
rvvlhdgdpnepvsdyinaniimpepkksyiatqgclqntvndfwrmvfqensrvivmtt
kevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwq
yhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilid
iirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

Timeline for d5i6vb3:

• d5i6vb3 is new in SCOPe 2.06-stable
  
• d5i6vb3 appears in SCOPe 2.07
  
• d5i6vb3 appears in the current release, SCOPe 2.08