Lineage for d5ibmb3 (5ibm B:219-524)

  1. Root: SCOPe 2.06
  2. 2089713Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2130872Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
  4. 2130873Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families) (S)
    share with the family I the common active site structure with a circularly permuted topology
  5. 2130985Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (7 proteins)
    has an extension to the beta-sheet of 3 antiparallel strands before strand 4
  6. 2131193Protein automated matches [190252] (3 species)
    not a true protein
  7. 2131194Species Human (Homo sapiens) [TaxId:9606] [187034] (28 PDB entries)
  8. 2131228Domain d5ibmb3: 5ibm B:219-524 [315470]
    Other proteins in same PDB: d5ibma1, d5ibma2, d5ibmb1, d5ibmb2
    automated match to d2shpa1
    mutant

Details for d5ibmb3

PDB Entry: 5ibm (more details), 2.18 Å

PDB Description: structure of s502p, a cancer-associated mutation of the oncogenic phosphatase shp2
PDB Compounds: (B:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d5ibmb3:

Sequence, based on SEQRES records: (download)

>d5ibmb3 c.45.1.2 (B:219-524) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrpgmvqteaqyrfiymav
qhyiet

Sequence, based on observed residues (ATOM records): (download)

>d5ibmb3 c.45.1.2 (B:219-524) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelskgfweefetlqqqeckllysrkegqrqenknknryknilpfdht
rvvlhdgdppvsdyinaniimpepkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrpgmvqteaqyrfiymavqhyiet

SCOPe Domain Coordinates for d5ibmb3:

Click to download the PDB-style file with coordinates for d5ibmb3.
(The format of our PDB-style files is described here.)

Timeline for d5ibmb3: