SCOPe 2.06: Domain d5flfb_: 5flf B:

Lineage for d5flfb_ (5flf B:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (32 PDB entries)

8. Domain d5flfb_: 5flf B: [314573]
   automated match to d4v04b_
   complexed with act, cl, pge, so4; mutant

Details for d5flfb_

PDB Entry: 5flf, 2.58 Å

PDB Description: disease linked mutation in fgfr

PDB Compounds: (B:) fibroblast growth factor receptor 1

SCOPe Domain Sequences for d5flfb_:

Sequence, based on SEQRES records:

>d5flfb_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
vseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksd
atekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrpp
gleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmki
adfglardihhidyykkttngrlpvkwmapealfdgiythqsdvwsfgvllweiftlggs
pypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldriva
ltsnq

Sequence, based on observed residues (ATOM records):

>d5flfb_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
vseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksd
atekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrpp
eqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglardihhid
yykkttngrlpvkwmapealfdgiythqsdvwsfgvllweiftlggspypgvpveelfkl
lkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnq

Timeline for d5flfb_:

• d5flfb_ is new in SCOPe 2.06-stable
  
• d5flfb_ appears in SCOPe 2.07
  
• d5flfb_ appears in the current release, SCOPe 2.08