SCOPe 2.06: Domain d5egua_: 5egu A:

Lineage for d5egua_ (5egu A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.2: Bromodomain [47370] (2 families)

5. Family a.29.2.0: automated matches [191428] (1 protein)
   not a true family

6. Protein automated matches [190615] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187641] (647 PDB entries)

8. Domain d5egua_: 5egu A: [313658]
   Other proteins in same PDB: d5egud2
   automated match to d4hbwa_
   complexed with 5nq, edo

Details for d5egua_

PDB Entry: 5egu, 2.21 Å

PDB Description: first domain of human bromodomain brd4 in complex with inhibitor 3- butyl-8-(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2- ylsulfanylmethyl)-7-ethyl-3,7-dihydropurine-2,6-dione

PDB Compounds: (A:) Bromodomain-containing protein 4

SCOPe Domain Sequences for d5egua_:

Sequence, based on SEQRES records:

>d5egua_ a.29.2.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiikt
pmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkine
lpte

Sequence, based on observed residues (ATOM records):

>d5egua_ a.29.2.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nppppetsnpnrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiiktpmd
mgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkinelpt
e

Timeline for d5egua_:

• d5egua_ is new in SCOPe 2.06-stable
  
• d5egua_ appears in SCOPe 2.07
  
• d5egua_ appears in the current release, SCOPe 2.08