Lineage for d4qwky_ (4qwk Y:)

  1. Root: SCOPe 2.08
  2. 2923792Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. 2988339Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
    4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
  4. 2988340Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families) (S)
    N-terminal residue provides two catalytic groups, nucleophile and proton donor
  5. 2988529Family d.153.1.4: Proteasome subunits [56251] (4 proteins)
  6. 2988641Protein Proteasome alpha subunit (non-catalytic) [56255] (10 species)
    contains an extension to the common fold at the N-terminus
  7. 2988657Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56257] (240 PDB entries)
    The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
  8. 2989036Domain d4qwky_: 4qwk Y: [308903]
    Other proteins in same PDB: d4qwka_, d4qwkb_, d4qwkc1, d4qwkc2, d4qwkf_, d4qwkh_, d4qwki_, d4qwkj_, d4qwkl_, d4qwkm_, d4qwkn_, d4qwko_, d4qwkp_, d4qwkq1, d4qwkq2, d4qwkt_, d4qwkv_, d4qwkw_, d4qwkx_, d4qwkz_
    automated match to d4g4sl_
    complexed with 3bv, cl, mes, mg; mutant

Details for d4qwky_

PDB Entry: 4qwk (more details), 2.8 Å

PDB Description: yCP beta5-A49T-A50V-double mutant in complex with carfilzomib
PDB Compounds: (Y:) Proteasome subunit beta type-5

SCOPe Domain Sequences for d4qwky_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4qwky_ d.153.1.4 (Y:) Proteasome alpha subunit (non-catalytic) {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
tttlafrfqggiivavdsratagnwvasqtvkkvieinpfllgtmaggtvdcqfwetwlg
sqcrlhelrekerisvaaaskilsnlvyqykgaglsmgtmicgytrkegptiyyvdsdgt
rlkgdifcvgsgqtfaygvldsnykwdlsvedalylgkrsilaaahrdaysggsvnlyhv
tedgwiyhgnhdvgelfwkvkeeegsfnnvig

SCOPe Domain Coordinates for d4qwky_:

Click to download the PDB-style file with coordinates for d4qwky_.
(The format of our PDB-style files is described here.)

Timeline for d4qwky_: