SCOPe 2.08: Domain d4b1ga_: 4b1g A:

Lineage for d4b1ga_ (4b1g A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.50: Macro domain-like [52948] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest

4. Superfamily c.50.1: Macro domain-like [52949] (4 families)

5. Family c.50.1.3: Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain-like [310642] (2 proteins)
   Pfam PF05028
   Contains N- and C-terminal extensions to macrodomain, including Tyr clasp, discussed in PubMed 22609859

6. Protein automated matches [310881] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [311355] (6 PDB entries)

8. Domain d4b1ga_: 4b1g A: [307034]
   automated match to d3ueka_
   complexed with dtv, so4

Details for d4b1ga_

PDB Entry: 4b1g, 1.83 Å

PDB Description: Structure of unliganded human PARG catalytic domain

PDB Compounds: (A:) Poly(ADP-ribose) glycohydrolase

SCOPe Domain Sequences for d4b1ga_:

Sequence, based on SEQRES records:

>d4b1ga_ c.50.1.3 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnkh
vkmpcseqnlypvedengertagsrweliqtallnkftrpqnlkdailkynvayskkwdf
talidfwdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeqi
asllanaffctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfcyfrrvtaaa
ptglvtftrqsledfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvtsa
glvqeeirflinpeliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgse
rddwqrrcteivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgnw
gcgafggdarlkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvyk
lllryyneecrncstpgpdiklypfiyhaves

Sequence, based on observed residues (ATOM records):

>d4b1ga_ c.50.1.3 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnkh
vkmpcseqnlypvrtagsrweliqtallnkftrpqnlkdailkynvayskkwdftalidf
wdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeqiasllan
affctfprrnaseyssypdinfnrlfegrssrkpeklktlfcyfrrvtaaaptglvtftr
qsledfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvtsaglvqeeirf
linpeliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgserddwqrrct
eivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgnwgcgafggda
rlkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvyklllryynee
crncpdiklypfiyhaves

Timeline for d4b1ga_:

• d4b1ga_ first appeared in SCOPe 2.06
  
• d4b1ga_ appears in SCOPe 2.07