SCOPe 2.08: Domain d3jrla_: 3jrl A:

Lineage for d3jrla_ (3jrl A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.0: automated matches [191381] (1 protein)
   not a true family

6. Protein automated matches [190475] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187400] (140 PDB entries)

8. Domain d3jrla_: 3jrl A: [305642]
   automated match to d4rdda_
   complexed with jzg

Details for d3jrla_

PDB Entry: 3jrl, 2 Å

PDB Description: Crystal structure of the oncogenic tyrosine phosphatase SHP2 complexed with a salicylic acid-based small molecule inhibitor

PDB Compounds: (A:) Oncogenic tyrosine phosphatase SHP2

SCOPe Domain Sequences for d3jrla_:

Sequence, based on SEQRES records:

>d3jrla_ c.45.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lysrkegqrqenknknryknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnns
kpkksyiatqgclqntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeyg
vmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldflee
vhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqr
sgmvqteaqyrfiymavqhyietlqr

Sequence, based on observed residues (ATOM records):

>d3jrla_ c.45.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lysrkegqrqenknknryknilpfdhtrvvlhdgdpnepvsdyinaniimpkksyiatqg
clqntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesa
ahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimda
gpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyr
fiymavqhyietlqr

Timeline for d3jrla_:

• d3jrla_ first appeared in SCOPe 2.06
  
• d3jrla_ appears in SCOPe 2.07