SCOP 1.67: Domain d1trb_2: 1trb 119-244

Lineage for d1trb_2 (1trb 119-244)

1. Root: SCOP 1.67

2. Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (5 families)

5. Family c.3.1.5: FAD/NAD-linked reductases, N-terminal and central domains [51943] (12 proteins)
   duplication: both domains have similar folds and functions
   most members of the family contain common C-terminal alpha+beta domain

6. Protein Thioredoxin reductase [51950] (2 species)
   lacks the "interface" C-terminal alpha+beta domain

7. Species Escherichia coli [TaxId:562] [51951] (5 PDB entries)

8. Domain d1trb_2: 1trb 119-244 [30530]
   complexed with fad; mutant

Details for d1trb_2

PDB Entry: 1trb, 2 Å

PDB Description: convergent evolution of similar function in two structurally divergent enzymes

SCOP Domain Sequences for d1trb_2:

Sequence; same for both SEQRES and ATOM records:

>d1trb_2 c.3.1.5 (119-244) Thioredoxin reductase {Escherichia coli}
lglpseeafkgrgvsacatsdgffyrnqkvavigggntaveealylsniasevhlihrrd
gfraekilikrlmdkvengniilhtnrtleevtgdqmgvtgvrlrdtqnsdniesldvag
lfvaig

Timeline for d1trb_2:

• d1trb_2 first appeared (with stable ids) in SCOP 1.55
  
• d1trb_2 appears in SCOP 1.65
  
• d1trb_2 appears in SCOP 1.69
  
• d1trb_2 appears in the current release, SCOPe 2.08, called d1trba2