SCOPe 2.08: Domain d3c4da1: 3c4d A:448-721

Lineage for d3c4da1 (3c4d A:448-721)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d3c4da1: 3c4d A:448-721 [305142]
   Other proteins in same PDB: d3c4da2, d3c4db2
   automated match to d4fk3a_
   complexed with 325; mutant

Details for d3c4da1

PDB Entry: 3c4d, 2.65 Å

PDB Description: B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX3203

PDB Compounds: (A:) B-Raf proto-oncogene serine/threonine-protein kinase

SCOPe Domain Sequences for d3c4da1:

Sequence, based on SEQRES records:

>d3c4da1 d.144.1.0 (A:448-721) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdyl
haksiihrdlksnniflhedntvkigdfglatvksrwsgshqfeqlsgsilwmapevirm
qdsnpysfqsdvyafgivlyelmtgqlpysninnrdqiiemvgrgslspdlskvrsncpk
rmkrlmaeclkkkrderpsfprilaeieelarel

Sequence, based on observed residues (ATOM records):

>d3c4da1 d.144.1.0 (A:448-721) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdyl
haksiihrdlksnniflhedntvkigdfgsgsilwmapevirmqdsnpysfqsdvyafgi
vlyelmtgqlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrder
psfprilaeieelarel

Timeline for d3c4da1:

• d3c4da1 first appeared in SCOPe 2.06
  
• d3c4da1 appears in SCOPe 2.07