SCOPe 2.06: Domain d2c5pc_: 2c5p C:

Lineage for d2c5pc_ (2c5p C:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (374 PDB entries)
   Uniprot P24941

8. Domain d2c5pc_: 2c5p C: [303643]
   Other proteins in same PDB: d2c5pb3, d2c5pb4, d2c5pd3, d2c5pd4
   automated match to d1h00a_
   complexed with ck7

Details for d2c5pc_

PDB Entry: 2c5p, 2.3 Å

PDB Description: differential binding of inhibitors to active and inactive cdk2 provides insights for drug design

PDB Compounds: (C:) Cell division protein kinase 2

SCOPe Domain Sequences for d2c5pc_:

Sequence; same for both SEQRES and ATOM records:

>d2c5pc_ d.144.1.7 (C:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

Timeline for d2c5pc_:

• d2c5pc_ is new in SCOPe 2.06-stable
  
• d2c5pc_ appears in SCOPe 2.07
  
• d2c5pc_ appears in the current release, SCOPe 2.08