SCOPe 2.08: Domain d5aava2: 5aav A:303-306

Lineage for d5aava2 (5aav A:303-306)

1. Root: SCOPe 2.08

2. Class l: Artifacts [310555] (1 fold)

3. Fold l.1: Tags [310573] (1 superfamily)

4. Superfamily l.1.1: Tags [310607] (1 family)

5. Family l.1.1.1: Tags [310682] (2 proteins)

6. Protein N-terminal Tags [310894] (1 species)

7. Species Synthetic [311501] (15360 PDB entries)

8. Domain d5aava2: 5aav A:303-306 [301774]
   Other proteins in same PDB: d5aava1, d5aavb_
   complexed with gw5

Details for d5aava2

PDB Entry: 5aav, 1.95 Å

PDB Description: optimization of a novel binding motif to to (e)-3-(3,5- difluoro-4-((1r,3r)-2-(2-fluoro-2-methylpropyl)-3-methyl-2, 3,4,9-tetrahydro-1h-pyrido(3,4-b)indol-1-yl)phenyl)acrylic acid (azd9496), a potent and orally bioavailable selective estrogen receptor downregulator and antagonist

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d5aava2:

Sequence; same for both SEQRES and ATOM records:

>d5aava2 l.1.1.1 (A:303-306) N-terminal Tags {Synthetic}
gshm

Timeline for d5aava2:

• d5aava2 first appeared in SCOPe 2.06
  
• d5aava2 appears in SCOPe 2.07