SCOP 1.71: Domain d1fds__: 1fds -

Lineage for d1fds__ (1fds -)

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (53 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51773] (16 PDB entries)

8. Domain d1fds__: 1fds - [29838]
   complexed with est

Details for d1fds__

PDB Entry: 1fds, 1.7 Å

PDB Description: human 17-beta-hydroxysteroid-dehydrogenase type 1 complexed with 17-beta-estradiol

SCOP Domain Sequences for d1fds__:

Sequence, based on SEQRES records:

>d1fds__ c.2.1.2 (-) Human estrogenic 17beta-hydroxysteroid dehydrogenase {Human (Homo sapiens)}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevfgdv

Sequence, based on observed residues (ATOM records):

>d1fds__ c.2.1.2 (-) Human estrogenic 17beta-hydroxysteroid dehydrogenase {Human (Homo sapiens)}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtvlgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevfltalr
apkptlryftterflpllrmrlddpsgsnyvtamhrevfgdv

Timeline for d1fds__:

• d1fds__ first appeared (with stable ids) in SCOP 1.55
  
• d1fds__ appears in SCOP 1.69
  
• d1fds__ is called d1fdsa_ in SCOP 1.73
  
• d1fds__ appears in the current release, SCOPe 2.08, called d1fdsa_