SCOPe 2.06: Domain d3u88a1: 3u88 A:2-230

Lineage for d3u88a1 (3u88 A:2-230)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.389: Menin N-terminal domain-like [310556] (1 superfamily)
   Some structural similarity to cysteine proteinases (d.3.1.4) noted in PubMed 22327296

4. Superfamily d.389.1: Menin N-terminal domain-like [310582] (1 family)
   Pfam PF05053

5. Family d.389.1.1: Menin N-terminal domain-like [310623] (1 protein)

6. Protein Menin N-terminal domain [310724] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [310972] (26 PDB entries)

8. Domain d3u88a1: 3u88 A:2-230 [295677]
   Other proteins in same PDB: d3u88a2, d3u88b2, d3u88c_, d3u88d_
   automated match to d3u85a1
   complexed with 0br, chd, ggb, glv, so4

Details for d3u88a1

PDB Entry: 3u88, 3 Å

PDB Description: crystal structure of human menin in complex with mll1 and ledgf

PDB Compounds: (A:) Menin

SCOPe Domain Sequences for d3u88a1:

Sequence, based on SEQRES records:

>d3u88a1 d.389.1.1 (A:2-230) Menin N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
glkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvpel
tfqpspapdppggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkkv
sdviwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsedh
awvvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrc

Sequence, based on observed residues (ATOM records):

>d3u88a1 d.389.1.1 (A:2-230) Menin N-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
glkaaqktlfplrsiddvvrlfaaelgreepdlvllslvlgfvehflavnrviptnvpel
tfqpspapdggltyfpvadlsiiaalyarftaqirgavdlslypreggvssrelvkkvsd
viwnslsrsyfkdrahiqslfsfitgtkldssgvafavvgacqalglrdvhlalsedhaw
vvfgpngeqtaevtwhgkgnedrrgqtvnagvaerswlylkgsymrc

Timeline for d3u88a1:

• d3u88a1 is new in SCOPe 2.06-stable
  
• d3u88a1 appears in SCOPe 2.07
  
• d3u88a1 appears in the current release, SCOPe 2.08