SCOP 1.75: Domain d1b3ob1: 1b3o B:10-111,B:232-499

Lineage for d1b3ob1 (1b3o B:10-111,B:232-499)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.5: Inosine monophosphate dehydrogenase (IMPDH) [51412] (1 family)
   The phosphate moiety of substrate binds in the 'common' phosphate-binding site

5. Family c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) [51413] (1 protein)

6. Protein Inosine monophosphate dehydrogenase (IMPDH) [51414] (8 species)

7. Species Human (Homo sapiens), type II [TaxId:9606] [51418] (3 PDB entries)

8. Domain d1b3ob1: 1b3o B:10-111,B:232-499 [28641]
   Other proteins in same PDB: d1b3ob4
   contains two CBS domains inserted into the common fold, residues 112-231
   complexed with cpr, sae

Details for d1b3ob1

PDB Entry: 1b3o, 2.9 Å

PDB Description: ternary complex of human type-ii inosine monophosphate dehydrogenase with 6-cl-imp and selenazole adenine dinucleotide

PDB Compounds: (B:) protein (inosine monophosphate dehydrogenase 2)

SCOP Domain Sequences for d1b3ob1:

Sequence, based on SEQRES records:

>d1b3ob1 c.1.5.1 (B:10-111,B:232-499) Inosine monophosphate dehydrogenase (IMPDH) {Human (Homo sapiens), type II [TaxId: 9606]}
tsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvssp
mdtvteagmaiamaltggigfihhnctpefqanevrkvkkyeXdyplaskdakkqllcga
aigtheddkyrldllaqagvdvvvldssqgnsifqinmikyikdkypnlqviggnvvtaa
qaknlidagvdalrvgmgsgsicitqevlacgrpqatavykvseyarrfgvpviadggiq
nvghiakalalgastvmmgsllaatteapgeyffsdgirlkkyrgmgsldamdkhlssqn
ryfseadkikvaqgvsgavqdkgsihkfvpyliagiqhscqdigaksltqvrammysgel
kfekrtssaqv

Sequence, based on observed residues (ATOM records):

>d1b3ob1 c.1.5.1 (B:10-111,B:232-499) Inosine monophosphate dehydrogenase (IMPDH) {Human (Homo sapiens), type II [TaxId: 9606]}
tsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvssp
mdtvteagmaiamaltggigfihhnctpefqanevrkvkkyeXdyplaskdakkqllcga
aigtheddkyrldllaqagvdvvvldssqgnsifqinmikyikdkypnlqviggnvvtaa
qaknlidagvdalrvgmgsgsicitqevlacgrpqatavykvseyarrfgvpviadggiq
nvghiakalalgastvmmgsllaatteapgeydkgsihkfvpyliagiqhscqdigaksl
tqvrammysgelkfekrtssaqv

Timeline for d1b3ob1:

• d1b3ob1 first appeared (with stable ids) in SCOP 1.55
  
• d1b3ob1 appears in SCOP 1.73
  
• d1b3ob1 appears in SCOPe 2.01
  
• d1b3ob1 appears in the current release, SCOPe 2.08