SCOPe 2.08: Domain d4xi3b_: 4xi3 B:

Lineage for d4xi3b_ (4xi3 B:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (107 PDB entries)
   Uniprot P03372 307-551

8. Domain d4xi3b_: 4xi3 B: [280506]
   automated match to d2qxsb_
   complexed with 29s

Details for d4xi3b_

PDB Entry: 4xi3, 2.49 Å

PDB Description: estrogen receptor alpha ligand binding domain in complex with bazedoxifene

PDB Compounds: (B:) Estrogen receptor

SCOPe Domain Sequences for d4xi3b_:

Sequence, based on SEQRES records:

>d4xi3b_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifd
mllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtl
ihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemld

Sequence, based on observed residues (ATOM records):

>d4xi3b_ a.123.1.1 (B:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
alsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvpg
fvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifd
mllatssrfrmmnlqgeefvclksiillnsgvyttlksleekdhihrvldkitdtlihlm
akagltlqqqhqrlaqlllilshirhmsnkgmehlysmknvvpsydlllemld

Timeline for d4xi3b_:

• d4xi3b_ first appeared in SCOPe 2.05
  
• d4xi3b_ appears in SCOPe 2.07