Lineage for d4xg7a1 (4xg7 A:364-635)

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2218047Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2218048Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2218179Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2220835Protein Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  7. 2220836Species Human (Homo sapiens) [TaxId:9606] [118132] (60 PDB entries)
    Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)
  8. 2220860Domain d4xg7a1: 4xg7 A:364-635 [280188]
    Other proteins in same PDB: d4xg7a2
    automated match to d3tuca_
    complexed with x7g

Details for d4xg7a1

PDB Entry: 4xg7 (more details), 1.76 Å

PDB Description: crystal structure of an inhibitor-bound syk
PDB Compounds: (A:) Tyrosine-protein kinase SYK

SCOPe Domain Sequences for d4xg7a1:

Sequence, based on SEQRES records: (download)

>d4xg7a1 d.144.1.7 (A:364-635) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
yldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaeanv
mqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmk
yleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyapec
inyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremyd
lmnlcwtydvenrpgfaavelrlrnyyydvvn

Sequence, based on observed residues (ATOM records): (download)

>d4xg7a1 d.144.1.7 (A:364-635) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
yldrklltledkelgtvkkgyyqmkkvvktvavkilkneapalkdellaeanvmqqldnp
yivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesnf
vhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyapecinyykfs
sksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwt
ydvenrpgfaavelrlrnyyydvvn

SCOPe Domain Coordinates for d4xg7a1:

Click to download the PDB-style file with coordinates for d4xg7a1.
(The format of our PDB-style files is described here.)

Timeline for d4xg7a1:

Domains from same chain:
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d4xg7a2