SCOPe 2.08: Domain d5bx0a_: 5bx0 A:

Lineage for d5bx0a_ (5bx0 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (2 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118138] (36 PDB entries)
   Uniprot Q02750 61-381

8. Domain d5bx0a_: 5bx0 A: [280009]
   automated match to d3eqca_
   complexed with 4w5

Details for d5bx0a_

PDB Entry: 5bx0, 2.93 Å

PDB Description: an automated microscale thermophoresis screening approach for fragment-based lead discovery

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d5bx0a_:

Sequence, based on SEQRES records:

>d5bx0a_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
eleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkl
ihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkka
gripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlids
mansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcq
vegdaaetpprprtpgrplnkkgmdsrppmaifelldyivnepppklpsgvfslefqdfv
nkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigln

Sequence, based on observed residues (ATOM records):

>d5bx0a_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
eleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkl
ihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkka
gripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlids
mansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcp
maifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdae
evdfagwlcstigln

Timeline for d5bx0a_:

• d5bx0a_ first appeared in SCOPe 2.05
  
• d5bx0a_ appears in SCOPe 2.07