SCOPe 2.08: Domain d5fp5a_: 5fp5 A:

Lineage for d5fp5a_ (5fp5 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d5fp5a_: 5fp5 A: [279834]
   automated match to d3ddqa_
   complexed with 1y6, ace

Details for d5fp5a_

PDB Entry: 5fp5, 2.16 Å

PDB Description: structure of cyclin-dependent kinase 2 with small-molecule ligand 4- fluorobenzoic acid (at222) in an alternate binding site.

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d5fp5a_:

Sequence, based on SEQRES records:

>d5fp5a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvph

Sequence, based on observed residues (ATOM records):

>d5fp5a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegygvvykarnkltgevvalkkitaireisllkelnhpnivklldviht
lylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdlkpqnlli
ntegaikladfgltlwyrapeillgckyystavdiwslgcifaemvtrralfpgdseidq
lfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvppldedgrsllsqmlhydp
nkrisakaalahpffqdvtkpvph

Timeline for d5fp5a_:

• d5fp5a_ first appeared in SCOPe 2.05
  
• d5fp5a_ appears in SCOPe 2.07