SCOPe 2.05: Domain d5cana_: 5can A:

Lineage for d5cana_ (5can A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (65 PDB entries)
   Uniprot P00533 702-1018

8. Domain d5cana_: 5can A: [278550]
   automated match to d4li5a_
   complexed with 4zb, so4; mutant

Details for d5cana_

PDB Entry: 5can, 2.8 Å

PDB Description: egfr kinase domain mutant "tmlr" with compound 27

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d5cana_:

Sequence, based on SEQRES records:

>d5cana_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaaaaeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylip

Sequence, based on observed residues (ATOM records):

>d5cana_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelatspkank
eildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnw
cvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgraklvpikwmalesilhriy
thqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcw
midadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfydmddvvdadeyli
p

Timeline for d5cana_:

• d5cana_ is new in SCOPe 2.05-stable
  
• d5cana_ appears in SCOPe 2.06
  
• d5cana_ appears in the current release, SCOPe 2.08