SCOPe 2.05: Domain d4qp8b_: 4qp8 B:

Lineage for d4qp8b_ (4qp8 B:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (12 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (553 PDB entries)

8. Domain d4qp8b_: 4qp8 B: [277296]
   automated match to d3sa0a_
   complexed with 362

Details for d4qp8b_

PDB Entry: 4qp8, 2.45 Å

PDB Description: crystal structure of erk2 in complex with 2-(1h-pyrazol-4-yl)-7- (pyridin-3-yl)-5h-pyrrolo[2,3-b]pyrazine

PDB Compounds: (B:) Mitogen-activated protein kinase 1

SCOPe Domain Sequences for d4qp8b_:

Sequence, based on SEQRES records:

>d4qp8b_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlrei
killrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyq
ilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatrw
yrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedl
nciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpy
leqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg

Sequence, based on observed residues (ATOM records):

>d4qp8b_ d.144.1.7 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlrei
killrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyq
ilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadlteyvatrwyrapeiml
nskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinlka
rnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydps
depiaeapfkfdmelddlpkeklkelifeetarfqpg

Timeline for d4qp8b_:

• d4qp8b_ is new in SCOPe 2.05-stable
  
• d4qp8b_ appears in SCOPe 2.06
  
• d4qp8b_ appears in the current release, SCOPe 2.08