Lineage for d5cf6a_ (5cf6 A:)

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1929110Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1929111Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1932524Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 1932525Protein automated matches [190417] (21 species)
    not a true protein
  7. 1932655Species Human (Homo sapiens) [TaxId:9606] [187294] (615 PDB entries)
  8. 1933420Domain d5cf6a_: 5cf6 A: [276321]
    automated match to d3q32b_
    complexed with 50o

Details for d5cf6a_

PDB Entry: 5cf6 (more details), 2.5 Å

PDB Description: crystal structure of janus kinase 2 in complex with n,n-dicyclopropyl- 10-[(2s)-2,3-dihydroxypropyl]-3-methyl-7-(methylamino)-3,5,8,10- tetraazatricyclo [7.3.0.02,6]dodeca-1(9),2(6),4,7,11-pentaene-11- carboxamide
PDB Compounds: (A:) Tyrosine-protein kinase JAK2

SCOPe Domain Sequences for d5cf6a_:

Sequence, based on SEQRES records: (download)

>d5cf6a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereiei
lkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqic
kgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwy
apeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliel
lknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma

Sequence, based on observed residues (ATOM records): (download)

>d5cf6a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereiei
lkslqhdnivkykgvcysrnlklimeylpygslrdylqkhkeridhikllqytsqickgm
eylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyape
slteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellkn
ngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma

SCOPe Domain Coordinates for d5cf6a_:

Click to download the PDB-style file with coordinates for d5cf6a_.
(The format of our PDB-style files is described here.)

Timeline for d5cf6a_: