SCOPe 2.05: Domain d5d1ja_: 5d1j A:

Lineage for d5d1ja_ (5d1j A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (348 PDB entries)
   Uniprot P24941

8. Domain d5d1ja_: 5d1j A: [275909]
   automated match to d1h00a_
   complexed with 56h

Details for d5d1ja_

PDB Entry: 5d1j, 1.8 Å

PDB Description: crystal structure of cyclin-dependent kinase 2 (cdk2-wt) complex with n-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl] methyl]thio]-2-thiazolyl]- 4-piperidinecarboxamide (bms-387032)

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d5d1ja_:

Sequence, based on SEQRES records:

>d5d1ja_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Sequence, based on observed residues (ATOM records):

>d5d1ja_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigeygvvykarnkltgevvalkkireisllkelnhpnivklldvihtenkl
ylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdlkpqnllin
tegaikladfvtlwyrapeillgckyystavdiwslgcifaemvtrralfpgdseidqlf
rifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvppldedgrsllsqmlhydpnk
risakaalahpffqdvtkpvphlrl

Timeline for d5d1ja_:

• d5d1ja_ is new in SCOPe 2.05-stable
  
• d5d1ja_ appears in SCOPe 2.06
  
• d5d1ja_ appears in the current release, SCOPe 2.08