Lineage for d5c25a1 (5c25 A:-1-429)

  1. Root: SCOPe 2.05
  2. 1949014Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)
  3. 1951566Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
    divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members
  4. 1951567Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families) (S)
    "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain
  5. 1951913Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)
  6. 1951914Protein HIV-1 reverse transcriptase [56689] (3 species)
  7. 1951956Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (153 PDB entries)
    Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595
  8. 1952193Domain d5c25a1: 5c25 A:-1-429 [275364]
    Other proteins in same PDB: d5c25a2
    automated match to d2be2a1
    protein/DNA complex; complexed with 639, mg, so4

Details for d5c25a1

PDB Entry: 5c25 (more details), 2.84 Å

PDB Description: crystal structure of hiv-1 reverse transcriptase in complex with 6- ((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-5,7-dimethyl-2- naphthonitrile (jlj639), a non-nucleoside inhibitor
PDB Compounds: (A:) HIV-1 reverse transcriptase, p66 subunit

SCOPe Domain Sequences for d5c25a1:

Sequence; same for both SEQRES and ATOM records: (download)

>d5c25a1 e.8.1.2 (A:-1-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
mvpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpynt
pvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsv
pldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfaaqnpdi
viyqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdk
wtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkaltevipltee
aelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmr
gahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvn
tpplvklwyql

SCOPe Domain Coordinates for d5c25a1:

Click to download the PDB-style file with coordinates for d5c25a1.
(The format of our PDB-style files is described here.)

Timeline for d5c25a1:

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Domains from same chain:
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d5c25a2
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Domains from other chains:
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d5c25b_