SCOPe 2.08: Domain d4zbil1: 4zbi L:172-321

Lineage for d4zbil1 (4zbi L:172-321)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [188549] (62 PDB entries)

8. Domain d4zbil1: 4zbi L:172-321 [272102]
   Other proteins in same PDB: d4zbia2, d4zbib2, d4zbic2, d4zbid2, d4zbie2, d4zbif2, d4zbig2, d4zbih2, d4zbii2, d4zbij2, d4zbik2, d4zbil2
   automated match to d2mhsa_
   complexed with 4m6

Details for d4zbil1

PDB Entry: 4zbi, 2.5 Å

PDB Description: mcl-1 complexed with small molecules

PDB Compounds: (L:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d4zbil1:

Sequence; same for both SEQRES and ATOM records:

>d4zbil1 f.1.4.1 (L:172-321) EAT/MCL-1 (Myeloid cell leukemia sequence 1) {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhv

Timeline for d4zbil1:

• d4zbil1 first appeared in SCOPe 2.05, called d4zbil_
  
• d4zbil1 appears in SCOPe 2.07