SCOPe 2.07: Domain d4yt6h_: 4yt6 H:

Lineage for d4yt6h_ (4yt6 H:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Coagulation factor VIIa [50550] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50551] (89 PDB entries)
   Uniprot P08709 213-466 ! Uniprot P08709 213-446

8. Domain d4yt6h_: 4yt6 H: [272083]
   Other proteins in same PDB: d4yt6l_
   automated match to d1klih_
   complexed with 4jy, ca, gol, so4

Details for d4yt6h_

PDB Entry: 4yt6, 2.07 Å

PDB Description: factor viia in complex with the inhibitor 4-{[(r)-[5-ethoxy-2-fluoro- 3-(propan-2-yloxy)phenyl](4-phenyl-1h-imidazol-2-yl) methyl]amino}benzenecarboximidamide

PDB Compounds: (H:) Coagulation factor VII (heavy chain)

SCOPe Domain Sequences for d4yt6h_:

Sequence; same for both SEQRES and ATOM records:

>d4yt6h_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

Timeline for d4yt6h_:

• d4yt6h_ first appeared in SCOPe 2.05
  
• d4yt6h_ appears in SCOPe 2.06
  
• d4yt6h_ appears in the current release, SCOPe 2.08