Lineage for d4rw4a1 (4rw4 A:-1-429)

  1. Root: SCOPe 2.05
  2. 1949014Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)
  3. 1951566Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
    divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members
  4. 1951567Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families) (S)
    "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain
  5. 1951913Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)
  6. 1952286Protein automated matches [190211] (5 species)
    not a true protein
  7. 1952317Species Human immunodeficiency virus type 1 bh10 [TaxId:11678] [225820] (18 PDB entries)
  8. 1952331Domain d4rw4a1: 4rw4 A:-1-429 [271954]
    Other proteins in same PDB: d4rw4a2, d4rw4b_
    automated match to d2ykna1
    complexed with 494

Details for d4rw4a1

PDB Entry: 4rw4 (more details), 2.67 Å

PDB Description: crystal structure of hiv-1 reverse transcriptase (k103n,y181c) variant in complex with (e)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2h)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (jlj494), a non-nucleoside inhibitor
PDB Compounds: (A:) Reverse transcriptase/ribonuclease H, p66 subunit

SCOPe Domain Sequences for d4rw4a1:

Sequence, based on SEQRES records: (download)

>d4rw4a1 e.8.1.2 (A:-1-429) automated matches {Human immunodeficiency virus type 1 bh10 [TaxId: 11678]}
mvpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpynt
pvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfsv
pldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfaaqnpdi
vicqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdk
wtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkaltevipltee
aelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmr
gahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvn
tpplvklwyql

Sequence, based on observed residues (ATOM records): (download)

>d4rw4a1 e.8.1.2 (A:-1-429) automated matches {Human immunodeficiency virus type 1 bh10 [TaxId: 11678]}
mvpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpynt
pvfaiwrklvdfrelnkrtqdfwgiphpaglkknksvtvldvgdayfsvpldedfrkyta
ftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfaaqnpdivicqymddlyv
gsdleigqhrtkieelrqhllrwglttpkeppflwmgyelhpdkwtvqpivlpekdswtv
ndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepv
hgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqk
ittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyql

SCOPe Domain Coordinates for d4rw4a1:

Click to download the PDB-style file with coordinates for d4rw4a1.
(The format of our PDB-style files is described here.)

Timeline for d4rw4a1:

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Domains from same chain:
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d4rw4a2
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Domains from other chains:
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d4rw4b_