Lineage for d4oexa1 (4oex A:535-860)

  1. Root: SCOPe 2.08
  2. 2685877Class a: All alpha proteins [46456] (290 folds)
  3. 2736615Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  4. 2736616Superfamily a.211.1: HD-domain/PDEase-like [109604] (9 families) (S)
  5. 2736712Family a.211.1.2: PDEase [48548] (7 proteins)
    Pfam PF00233; multihelical; can be divided into three subdomains
  6. 2737088Protein automated matches [190370] (2 species)
    not a true protein
  7. 2737094Species Human (Homo sapiens) [TaxId:9606] [187208] (27 PDB entries)
  8. 2737117Domain d4oexa1: 4oex A:535-860 [270982]
    Other proteins in same PDB: d4oexa2
    automated match to d3ly2a_
    complexed with 5eo, mg, zn

Details for d4oexa1

PDB Entry: 4oex (more details), 2.14 Å

PDB Description: crystal structure of the pde5a1 catalytic domain in complex with novel inhibitors
PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d4oexa1:

Sequence, based on SEQRES records: (download)

>d4oexa1 a.211.1.2 (A:535-860) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
vsedcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records): (download)

>d4oexa1 a.211.1.2 (A:535-860) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatdl
alyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvate
ffdqgknkipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq

SCOPe Domain Coordinates for d4oexa1:

Click to download the PDB-style file with coordinates for d4oexa1.
(The format of our PDB-style files is described here.)

Timeline for d4oexa1:

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Domains from same chain:
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d4oexa2