SCOPe 2.08: Domain d4rx2c_: 4rx2 C:

Lineage for d4rx2c_ (4rx2 C:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.3: beta-lactamase/transpeptidase-like [56600] (1 superfamily)
   contains a cluster of helices and an alpha+beta sandwich

4. Superfamily e.3.1: beta-lactamase/transpeptidase-like [56601] (4 families)

5. Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase [56602] (19 proteins)
   in the multi-domain class (e), this applies to domains with different numbers of (sub)domains than the most common domain
   

6. Protein beta-Lactamase, class A [56606] (16 species)

7. Species Escherichia coli, TEM-1 [TaxId:562] [56607] (63 PDB entries)

8. Domain d4rx2c_: 4rx2 C: [269880]
   automated match to d1fqga_
   complexed with so4; mutant

Details for d4rx2c_

PDB Entry: 4rx2, 2.31 Å

PDB Description: a triple mutant in the omega-loop of tem-1 beta-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis

PDB Compounds: (C:) Beta-lactamase TEM

SCOPe Domain Sequences for d4rx2c_:

Sequence, based on SEQRES records:

>d4rx2c_ e.3.1.1 (C:) beta-Lactamase, class A {Escherichia coli, TEM-1 [TaxId: 562]}
hpetlvkvkdaedqlgarvgyieldlnsgkilesfrpeerfpmmstfkvllcgavlsrvd
agqeqlgrrihysqndlveyspvtekhltdgmtvrelcsaaitmsdntaanlllttiggp
keltaflhnmgdhvtrldryygelneaipnderdtttpaamattlrklltgelltlasrq
qlidwmeadkvagpllrsalpagwfiadksgagergsrgiiaalgpdgkpsrivviyttg
sqatmdernrqiaeigaslikhw

Sequence, based on observed residues (ATOM records):

>d4rx2c_ e.3.1.1 (C:) beta-Lactamase, class A {Escherichia coli, TEM-1 [TaxId: 562]}
hpetlvkvkdaedqlgarvgyieldlnsgkilesfrpeerfpmmstfkvllcgavlsrvd
agqeqlgrrihysqndlveyspvtekhltdgmtvrelcsaaitmsdntaanlllttiggp
keltaflhnmgdhvtrldryygipnderdtttpaamattlrklltgelltlasrqqlidw
meadkvagpllrsalpagwfiadksgagergsrgiiaalgpdgkpsrivviyttgsqatm
dernrqiaeigaslikhw

Timeline for d4rx2c_:

• d4rx2c_ first appeared in SCOPe 2.05
  
• d4rx2c_ appears in SCOPe 2.07