SCOPe 2.08: Domain d4s1gb_: 4s1g B:

Lineage for d4s1gb_ (4s1g B:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (77 PDB entries)

8. Domain d4s1gb_: 4s1g B: [269377]
   automated match to d2rena_
   complexed with 43t, nag

Details for d4s1gb_

PDB Entry: 4s1g, 2.1 Å

PDB Description: renin in complex with (s)-1-(3-fluoro-5-(((s)-1-phenylethyl) carbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin- 2(1h)-iminium

PDB Compounds: (B:) renin

SCOPe Domain Sequences for d4s1gb_:

Sequence, based on SEQRES records:

>d4s1gb_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvy
hklfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfm
laefdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlgg
sdpqhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssie
klmealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlai
hamdippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records):

>d4s1gb_ b.50.1.2 (B:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
ltlgnttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvy
hklfdasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfm
laefdgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdssqslggqivlggsd
pqhyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssiekl
mealgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaiha
mdippptgptwalgatfirkfytefdrrnnrigfalar

Timeline for d4s1gb_:

• d4s1gb_ first appeared in SCOPe 2.05
  
• d4s1gb_ appears in SCOPe 2.07