SCOPe 2.05: Domain d4x2ja_: 4x2j A:

Lineage for d4x2ja_ (4x2j A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Type I TGF-beta receptor R4 [56144] (1 species)
   TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

7. Species Human (Homo sapiens) [TaxId:9606] [56145] (16 PDB entries)
   Uniprot P36897 200-500 ! Uniprot P36897 201-503

8. Domain d4x2ja_: 4x2j A: [269169]
   automated match to d1vjya_
   complexed with 3wn, so4

Details for d4x2ja_

PDB Entry: 4x2j, 1.69 Å

PDB Description: Selection of fragments for kinase inhibitor design: decoration is key

PDB Compounds: (A:) TGF-beta receptor type-1

SCOPe Domain Sequences for d4x2ja_:

Sequence; same for both SEQRES and ATOM records:

>d4x2ja_ d.144.1.7 (A:) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
gtiartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhen
ilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhm
eivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkry
mapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsv
eemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqq
egi

Timeline for d4x2ja_:

• d4x2ja_ is new in SCOPe 2.05-stable
  
• d4x2ja_ is called d4x2ja1 in SCOPe 2.06
  
• d4x2ja_ appears in the current release, SCOPe 2.08, called d4x2ja1