SCOPe 2.08: Domain d4x2ja1: 4x2j A:200-501

Lineage for d4x2ja1 (4x2j A:200-501)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Type I TGF-beta receptor R4 [56144] (1 species)
   TKL group; STKR subfamily; serine/threonine kinase; possible evolutionary link to tyrosine kinases

7. Species Human (Homo sapiens) [TaxId:9606] [56145] (32 PDB entries)
   Uniprot P36897 200-500 ! Uniprot P36897 201-503

8. Domain d4x2ja1: 4x2j A:200-501 [269169]
   Other proteins in same PDB: d4x2ja2
   automated match to d1vjya_
   complexed with 3wn, so4

Details for d4x2ja1

PDB Entry: 4x2j, 1.69 Å

PDB Description: Selection of fragments for kinase inhibitor design: decoration is key

PDB Compounds: (A:) TGF-beta receptor type-1

SCOPe Domain Sequences for d4x2ja1:

Sequence; same for both SEQRES and ATOM records:

>d4x2ja1 d.144.1.7 (A:200-501) Type I TGF-beta receptor R4 {Human (Homo sapiens) [TaxId: 9606]}
tiartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrheni
lgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlhme
ivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkrym
apevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdpsve
emrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsqqe
gi

Timeline for d4x2ja1:

• d4x2ja1 first appeared in SCOPe 2.05, called d4x2ja_
  
• d4x2ja1 appears in SCOPe 2.07