SCOPe 2.05: Domain d4qsme2: 4qsm E:161-332

Lineage for d4qsme2 (4qsm E:161-332)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
   unusual fold, defines family

4. Superfamily d.162.1: LDH C-terminal domain-like [56327] (3 families)

5. Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (5 proteins)
   N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
   automatically mapped to Pfam PF02866

6. Protein Lactate dehydrogenase [56339] (18 species)

7. Species Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [64445] (13 PDB entries)

8. Domain d4qsme2: 4qsm E:161-332 [267358]
   Other proteins in same PDB: d4qsma1, d4qsmb1, d4qsmc1, d4qsmd1, d4qsme1, d4qsmf1, d4qsmg1, d4qsmh1
   automated match to d4l4ra2
   complexed with 38k

Details for d4qsme2

PDB Entry: 4qsm, 3 Å

PDB Description: crystal structure of human muscle l-lactate dehydrogenase in complex with inhibitor 2, 3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3- sulfamoylquinolin-4-yl]amino}benzoic acid

PDB Compounds: (E:) L-lactate dehydrogenase A chain

SCOPe Domain Sequences for d4qsme2:

Sequence; same for both SEQRES and ATOM records:

>d4qsme2 d.162.1.1 (E:161-332) Lactate dehydrogenase {Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]}
sgcnldsarfrylmgerlgvhplschgwvlgehgdssvpvwsgmnvagvslktlhpdlgt
dkdkeqwkevhkqvvesayeviklkgytswaiglsvadlaesimknlrrvhpvstmikgl
ygikddvflsvpcilgqngisdlvkvtltseeearlkksadtlwgiqkelqf

Timeline for d4qsme2:

• d4qsme2 is new in SCOPe 2.05-stable
  
• d4qsme2 appears in SCOPe 2.06
  
• d4qsme2 appears in the current release, SCOPe 2.08