SCOPe 2.08: Domain d4mibb1: 4mib B:2-562

Lineage for d4mibb1 (4mib B:2-562)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein Viral RNA polymerase [56695] (17 species)

7. Species Hepatitis C virus [TaxId:420174] [188905] (22 PDB entries)

8. Domain d4mibb1: 4mib B:2-562 [266736]
   Other proteins in same PDB: d4miba2, d4mibb2
   automated match to d3gnwb_
   complexed with 28m, dms

Details for d4mibb1

PDB Entry: 4mib, 2.3 Å

PDB Description: Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with Compound 48 (N-({(3S)-1-[6-tert-butyl-5-methoxy-8-(2-oxo-1,2-dihydropyridin-3-yl)quinolin-3-yl]pyrrolidin-3-yl}methyl)methanesulfonamide)

PDB Compounds: (B:) RNA-directed RNA polymerase

SCOPe Domain Sequences for d4mibb1:

Sequence, based on SEQRES records:

>d4mibb1 e.8.1.4 (B:2-562) Viral RNA polymerase {Hepatitis C virus [TaxId: 420174]}
msytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvld
dhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihs
vwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvst
lpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyq
ccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasa
acraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydle
litscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwa
rmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspge
inrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipa
asrldlsgwfvagysggdiyh

Sequence, based on observed residues (ATOM records):

>d4mibb1 e.8.1.4 (B:2-562) Viral RNA polymerase {Hepatitis C virus [TaxId: 420174]}
msytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvld
dhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihs
vwkdlledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqvv
mgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdla
pearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraa
klqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelitsc
ssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilm
thffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrva
sclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpipaasrld
lsgwfvagysggdiyh

Timeline for d4mibb1:

• d4mibb1 first appeared in SCOPe 2.05, called d4mibb_
  
• d4mibb1 appears in SCOPe 2.07