SCOP 1.71: Domain d1hshd_: 1hsh D:

Lineage for d1hshd_ (1hsh D:)

1. Root: SCOP 1.71

2. Class b: All beta proteins [48724] (149 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (2 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (8 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (1 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (179 PDB entries)

8. Domain d1hshd_: 1hsh D: [26566]
   complexed with mk1

Details for d1hshd_

PDB Entry: 1hsh, 1.9 Å

PDB Description: crystal structure at 1.9 angstroms resolution of human immunodeficiency virus (hiv) ii protease complexed with l-735,524, an orally bioavailable inhibitor of the hiv proteases

SCOP Domain Sequences for d1hshd_:

Sequence; same for both SEQRES and ATOM records:

>d1hshd_ b.50.1.1 (D:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1}
pqfslwkrpvvtayiegqpvevlldtgaddsivagielgnnyspkivggiggfintkeyk
nveievlnkkvratimtgdtpinifgrniltalgmslnl

Timeline for d1hshd_:

• d1hshd_ first appeared (with stable ids) in SCOP 1.55
  
• d1hshd_ appears in SCOP 1.69
  
• d1hshd_ appears in SCOP 1.73
  
• d1hshd_ appears in the current release, SCOPe 2.08