SCOPe 2.06: Domain d4pwda1: 4pwd A:1-429

Lineage for d4pwda1 (4pwd A:1-429)

1. Root: SCOPe 2.06

2. Class e: Multi-domain proteins (alpha and beta) [56572] (69 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein automated matches [190211] (6 species)
   not a true protein

7. Species Human immunodeficiency virus type 1 bh10 [TaxId:11678] [225820] (18 PDB entries)

8. Domain d4pwda1: 4pwd A:1-429 [263579]
   Other proteins in same PDB: d4pwda2, d4pwda3, d4pwdb_, d4pwdc2, d4pwdc3, d4pwdd_
   automated match to d2ykna1
   protein/DNA complex; protein/RNA complex; complexed with ca, nvp, so4

Details for d4pwda1

PDB Entry: 4pwd, 3 Å

PDB Description: Crystal structure of HIV-1 reverse transcriptase in complex with bulge-RNA/DNA and Nevirapine

PDB Compounds: (A:) HIV-1 reverse transcriptase, p66 subunit

SCOPe Domain Sequences for d4pwda1:

Sequence; same for both SEQRES and ATOM records:

>d4pwda1 e.8.1.2 (A:1-429) automated matches {Human immunodeficiency virus type 1 bh10 [TaxId: 11678]}
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndicklvgklnwasqiypgikvrqlskllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyql

Timeline for d4pwda1:

• d4pwda1 first appeared in SCOPe 2.05
  
• d4pwda1 appears in SCOPe 2.07
  
• d4pwda1 appears in the current release, SCOPe 2.08