SCOPe 2.08: Domain d4ohlb3: 4ohl B:219-526

Lineage for d4ohlb3 (4ohl B:219-526)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.0: automated matches [191381] (1 protein)
   not a true family

6. Protein automated matches [190475] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187400] (140 PDB entries)

8. Domain d4ohlb3: 4ohl B:219-526 [263290]
   Other proteins in same PDB: d4ohla1, d4ohla2, d4ohlb1, d4ohlb2
   automated match to d2b3oa3
   mutant

Details for d4ohlb3

PDB Entry: 4ohl, 2.4 Å

PDB Description: LEOPARD Syndrome-Associated SHP2/T468M mutant

PDB Compounds: (B:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d4ohlb3:

Sequence, based on SEQRES records:

>d4ohlb3 c.45.1.0 (B:219-526) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgmfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymav
qhyietlq

Sequence, based on observed residues (ATOM records):

>d4ohlb3 c.45.1.0 (B:219-526) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelskgfweefetlqqqeckllysrkegqrqenknknryknilpfdht
rvvlhdsdyinaniimpksyiatqgclqntvndfwrmvfqensrvivmttkevergkskc
vkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhg
vpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgmfividilidiirekgvdcd
idvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlq

Timeline for d4ohlb3:

• d4ohlb3 first appeared in SCOPe 2.05
  
• d4ohlb3 appears in SCOPe 2.07