SCOPe 2.03: Domain d1hlt.2: 1hlt J:,K:

Lineage for d1hlt.2 (1hlt J:,K:)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (168 PDB entries)
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d1hlt.2: 1hlt J:,K: [26182]
   complexed with 0g6

Details for d1hlt.2

PDB Entry: 1hlt, 3 Å

PDB Description: the structure of a nonadecapeptide of the fifth egf domain of thrombomodulin complexed with thrombin

PDB Compounds: (J:) alpha-thrombin (small subunit), (K:) alpha-thrombin (large subunit)

SCOPe Domain Sequences for d1hlt.2:

Sequence, based on SEQRES records:

>g1hlt.2 b.47.1.2 (J:,K:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
adcglrplfekksledkterellesyiXivegsdaeigmspwqvmlfrkspqellcgasl
isdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynw
renldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwtanv
gkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmk
spfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidq

Sequence, based on observed residues (ATOM records):

>g1hlt.2 b.47.1.2 (J:,K:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
adcglrplfekksledkterellesyiXivegsdaeigmspwqvmlfrkspqellcgasl
isdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynw
renldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwtgqp
svlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspfnn
rwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidq

Timeline for d1hlt.2:

• d1hlt.2 first appeared (with stable ids) in SCOP 1.55
  
• d1hlt.2 appears in SCOPe 2.02
  
• d1hlt.2 appears in SCOPe 2.04
  
• d1hlt.2 appears in the current release, SCOPe 2.08