Lineage for d4cqeb_ (4cqe B:)

  1. Root: SCOPe 2.04
  2. 1631855Class d: Alpha and beta proteins (a+b) [53931] (380 folds)
  3. 1671717Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1671718Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1674829Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 1674830Protein automated matches [190417] (19 species)
    not a true protein
  7. 1674960Species Human (Homo sapiens) [TaxId:9606] [187294] (476 PDB entries)
  8. 1675478Domain d4cqeb_: 4cqe B: [261647]
    automated match to d4fk3a_
    complexed with cqe; mutant

Details for d4cqeb_

PDB Entry: 4cqe (more details), 2.3 Å

PDB Description: b-raf kinase v600e mutant in complex with a diarylthiazole b-raf inhibitor
PDB Compounds: (B:) slc45a3-braf fusion protein

SCOPe Domain Sequences for d4cqeb_:

Sequence, based on SEQRES records: (download)

>d4cqeb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrk
trhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdyl
haksiihrdlksnniflhedntvkigdfglateksrwsgshqfeqlsgsilwmapevirm
qdsnpysfqsdvyafgivlyelmtgqlpysninnrdqiiemvgrgslspdlskvrsncpk
rmkrlmaeclkkkrderpsfprilaeieelare

Sequence, based on observed residues (ATOM records): (download)

>d4cqeb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ddweipdgqitvgqrigsgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrktrh
vnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdylhak
siihrdlksnniflhedntvkigdfggsilwmapevirnpysfqsdvyafgivlyelmtg
qlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrderpsfprila
eieelare

SCOPe Domain Coordinates for d4cqeb_:

Click to download the PDB-style file with coordinates for d4cqeb_.
(The format of our PDB-style files is described here.)

Timeline for d4cqeb_: