SCOPe 2.05: Domain d4nwfb3: 4nwf B:219-533

Lineage for d4nwfb3 (4nwf B:219-533)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.0: automated matches [191381] (1 protein)
   not a true family

6. Protein automated matches [190475] (8 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187400] (99 PDB entries)

8. Domain d4nwfb3: 4nwf B:219-533 [261533]
   Other proteins in same PDB: d4nwfa1, d4nwfa2, d4nwfb1, d4nwfb2
   automated match to d2b3oa3
   complexed with edo, gol; mutant

Details for d4nwfb3

PDB Entry: 4nwf, 2.1 Å

PDB Description: Crystal structure of the tyrosine phosphatase SHP-2 with N308D mutation

PDB Compounds: (B:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d4nwfb3:

Sequence, based on SEQRES records:

>d4nwfb3 c.45.1.0 (B:219-533) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinadiimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymav
qhyietlqrrieeeq

Sequence, based on observed residues (ATOM records):

>d4nwfb3 c.45.1.0 (B:219-533) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelskgfweefetlqqqeckllysrkegqrqenknknryknilpfdht
rvvlhdgdpnvsdyinadiimpeksyiatqgclqntvndfwrmvfqensrvivmttkeve
rgkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfr
twpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiire
kgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqrrieeeq

Timeline for d4nwfb3:

• d4nwfb3 first appeared in SCOPe 2.04
  
• d4nwfb3 appears in SCOPe 2.06
  
• d4nwfb3 appears in the current release, SCOPe 2.08