SCOPe 2.05: Domain d4wuna_: 4wun A:

Lineage for d4wuna_ (4wun A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (29 PDB entries)

8. Domain d4wuna_: 4wun A: [261201]
   automated match to d4nkab_
   complexed with 66t

Details for d4wuna_

PDB Entry: 4wun, 1.65 Å

PDB Description: structure of fgfr1 in complex with azd4547 (n-{3-[2-(3,5- dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5- dimethylpiperazin-1-yl]benzamide) at 1.65 angstrom

PDB Compounds: (A:) fibroblast growth factor receptor 1

SCOPe Domain Sequences for d4wuna_:

Sequence, based on SEQRES records:

>d4wuna_ d.144.1.7 (A:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
lpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdatekd
lsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppgleys
ynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfgl
ardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgv
pveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnq
e

Sequence, based on observed residues (ATOM records):

>d4wuna_ d.144.1.7 (A:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
lpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdatekd
lsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppleysy
npshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglp
vkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkps
nctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnqe

Timeline for d4wuna_:

• d4wuna_ first appeared in SCOPe 2.04
  
• d4wuna_ appears in SCOPe 2.06
  
• d4wuna_ appears in the current release, SCOPe 2.08