SCOPe 2.06: Domain d4umxb_: 4umx B:

Lineage for d4umxb_ (4umx B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein automated matches [190072] (19 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189131] (7 PDB entries)

8. Domain d4umxb_: 4umx B: [261172]
   automated match to d4l03c_
   complexed with gol, nap, vvs

Details for d4umxb_

PDB Entry: 4umx, 1.88 Å

PDB Description: idh1 r132h in complex with cpd 1

PDB Compounds: (B:) isocitrate dehydrogenase [nadp] cytoplasmic

SCOPe Domain Sequences for d4umxb_:

Sequence, based on SEQRES records:

>d4umxb_ c.77.1.1 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgm
ynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaq
kiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvcpdgkt
veaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleev
sietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

Sequence, based on observed residues (ATOM records):

>d4umxb_ c.77.1.1 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgm
ynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaq
kiwyehrliddmvaqamkseggfiwacknydgdvqsgslgmmtsvlvcpdgktveaeaah
gtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietiea
gfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

Timeline for d4umxb_:

• d4umxb_ first appeared in SCOPe 2.04
  
• d4umxb_ appears in SCOPe 2.05
  
• d4umxb_ appears in SCOPe 2.07
  
• d4umxb_ appears in the current release, SCOPe 2.08