SCOPe 2.04: Domain d4qyya_: 4qyy A:

Lineage for d4qyya_ (4qyy A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase Erk2 [56134] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Norway rat (Rattus norvegicus) [TaxId:10116] [56136] (19 PDB entries)

8. Domain d4qyya_: 4qyy A: [260957]
   automated match to d2erka_
   complexed with 3g7, so4

Details for d4qyya_

PDB Entry: 4qyy, 1.65 Å

PDB Description: Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State

PDB Compounds: (A:) Mitogen-activated protein kinase 1

SCOPe Domain Sequences for d4qyya_:

Sequence, based on SEQRES records:

>d4qyya_ d.144.1.7 (A:) MAP kinase Erk2 {Norway rat (Rattus norvegicus) [TaxId: 10116]}
rgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrtlreiki
llrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqil
rglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatrwyr
apeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnc
iinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyle
qyydpsdepiaeapfkfdmelddlpkeklkelifeetarfq

Sequence, based on observed residues (ATOM records):

>d4qyya_ d.144.1.7 (A:) MAP kinase Erk2 {Norway rat (Rattus norvegicus) [TaxId: 10116]}
rgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrtlreiki
llrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqil
rglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatrwyr
apeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnc
iinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyle
qyydpsdepiaeapfklddlpkeklkelifeetarfq

Timeline for d4qyya_:

• d4qyya_ is new in SCOPe 2.04-stable
  
• d4qyya_ appears in SCOPe 2.05
  
• d4qyya_ appears in the current release, SCOPe 2.08