Lineage for d4m2xe_ (4m2x E:)

  1. Root: SCOPe 2.04
  2. 1565955Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 1618271Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 1618272Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 1618684Family c.71.1.0: automated matches [191485] (1 protein)
    not a true family
  6. 1618685Protein automated matches [190777] (17 species)
    not a true protein
  7. 1618842Species Mycobacterium tuberculosis [TaxId:1773] [230073] (6 PDB entries)
  8. 1618854Domain d4m2xe_: 4m2x E: [260894]
    automated match to d4klxa_
    complexed with act, ndp, po4, tmq

Details for d4m2xe_

PDB Entry: 4m2x (more details), 2.26 Å

PDB Description: Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)
PDB Compounds: (E:) dihydrofolate reductase

SCOPe Domain Sequences for d4m2xe_:

Sequence; same for both SEQRES and ATOM records: (download)

>d4m2xe_ c.71.1.0 (E:) automated matches {Mycobacterium tuberculosis [TaxId: 1773]}
mvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplpgr
rnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdiglp
reagdalapvldetwrgetgewrfsrsglryrlysyhrs

SCOPe Domain Coordinates for d4m2xe_:

Click to download the PDB-style file with coordinates for d4m2xe_.
(The format of our PDB-style files is described here.)

Timeline for d4m2xe_: