SCOPe 2.08: Domain d4wiva1: 4wiv A:44-168

Lineage for d4wiva1 (4wiv A:44-168)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.2: Bromodomain [47370] (2 families)

5. Family a.29.2.0: automated matches [191428] (1 protein)
   not a true family

6. Protein automated matches [190615] (15 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187641] (1052 PDB entries)

8. Domain d4wiva1: 4wiv A:44-168 [260854]
   Other proteins in same PDB: d4wiva2
   automated match to d3u5la_
   complexed with 3p2, edo, gol

Details for d4wiva1

PDB Entry: 4wiv, 1.56 Å

PDB Description: crystal structure of the first bromodomain of human brd4 in complex with a novel inhibitor umb32 (n-tert-butyl-2-[4-(3,5-dimethyl-1,2- oxazol-4-yl) phenyl]imidazo[1,2-a]pyrazin-3-amine)

PDB Compounds: (A:) Bromodomain-containing protein 4

SCOPe Domain Sequences for d4wiva1:

Sequence; same for both SEQRES and ATOM records:

>d4wiva1 a.29.2.0 (A:44-168) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiikt
pmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkine
lptee

Timeline for d4wiva1:

• d4wiva1 first appeared in SCOPe 2.04, called d4wiva_
  
• d4wiva1 appears in SCOPe 2.07