SCOPe 2.08: Domain d4ktxa1: 4ktx A:1-425

Lineage for d4ktxa1 (4ktx A:1-425)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ('zincins'), catalytic domain [55486] (18 families)

5. Family d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (2 proteins)

6. Protein Botulinum neurotoxin [55513] (4 species)

7. Species Clostridium botulinum, serotype A [TaxId:1491] [55514] (29 PDB entries)
   Uniprot P10845 1-419

8. Domain d4ktxa1: 4ktx A:1-425 [260313]
   Other proteins in same PDB: d4ktxa2
   automated match to d4ej5a_
   complexed with gol, pgo, so4, zn; mutant

Details for d4ktxa1

PDB Entry: 4ktx, 2.59 Å

PDB Description: crystal structure of the catalytic domain of botulinum neurotoxin bont/a c134s mutant with covalent inhibitor that modifies cys-165 causing disorder in 167-174 stretch

PDB Compounds: (A:) Botulinum neurotoxin A light chain

SCOPe Domain Sequences for d4ktxa1:

Sequence; same for both SEQRES and ATOM records:

>d4ktxa1 d.92.1.7 (A:1-425) Botulinum neurotoxin {Clostridium botulinum, serotype A [TaxId: 1491]}
mpfvnkqfnykdpvngvdiayikipnagqmqpvkafkihnkiwviperdtftnpeegdln
pppeakqvpvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwgg
stidtelkvidtnsinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltrngy
gstqyirfspdftfgfeeslevdtnpllgagkfatdpavtlahelihaghrlygiainpn
rvfkvntnayyemsglevsfeelrtfgghdakfidslqenefrlyyynkfkdiastlnka
ksivgttaslqymknvfkekyllsedtsgkfsvdklkfdklykmlteiytednfvkffkv
lnrktylnfdkavfkinivpkvnytiydgfnlrntnlaanfngqnteinnmnftklknft
glfef

Timeline for d4ktxa1:

• d4ktxa1 first appeared in SCOPe 2.04, called d4ktxa_
  
• d4ktxa1 appears in SCOPe 2.07