SCOPe 2.06: Domain d4ohea2: 4ohe A:111-218

Lineage for d4ohea2 (4ohe A:111-218)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.0: automated matches [191409] (1 protein)
   not a true family

6. Protein automated matches [190561] (4 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187549] (49 PDB entries)

8. Domain d4ohea2: 4ohe A:111-218 [259872]
   Other proteins in same PDB: d4ohea3
   automated match to d2b3oa2
   mutant

Details for d4ohea2

PDB Entry: 4ohe, 2.51 Å

PDB Description: LEOPARD Syndrome-Associated SHP2/G464A mutant

PDB Compounds: (A:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d4ohea2:

Sequence, based on SEQRES records:

>d4ohea2 d.93.1.0 (A:111-218) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthv
mircqelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnt

Sequence, based on observed residues (ATOM records):

>d4ohea2 d.93.1.0 (A:111-218) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtkskvthvmircqelkyd
vgggerfdsltdlvehykknpmvetlgtvlqlkqplnt

Timeline for d4ohea2:

• d4ohea2 first appeared in SCOPe 2.04
  
• d4ohea2 appears in SCOPe 2.05
  
• d4ohea2 appears in SCOPe 2.07
  
• d4ohea2 appears in the current release, SCOPe 2.08