Lineage for d4pv0a_ (4pv0 A:)

  1. Root: SCOPe 2.04
  2. 1631855Class d: Alpha and beta proteins (a+b) [53931] (380 folds)
  3. 1671717Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1671718Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1671838Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1673918Protein Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  7. 1673919Species Human (Homo sapiens) [TaxId:9606] [118132] (27 PDB entries)
    Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)
  8. 1673939Domain d4pv0a_: 4pv0 A: [257561]
    automated match to d4fyoa_
    complexed with cg4, cl

Details for d4pv0a_

PDB Entry: 4pv0 (more details), 2 Å

PDB Description: crystal structure of spleen tyrosine kinase (syk) in complex with an imidazopyrazine inhibitor
PDB Compounds: (A:) Tyrosine-protein kinase SYK

SCOPe Domain Sequences for d4pv0a_:

Sequence, based on SEQRES records: (download)

>d4pv0a_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaean
vmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgm
kyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyape
cinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremy
dlmnlcwtydvenrpgfaavelrlrnyyydvvneg

Sequence, based on observed residues (ATOM records): (download)

>d4pv0a_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
vyldrklltledkelgsfgtvkkgyyqmkkvvktvavkilkpalkdellaeanvmqqldn
pyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesn
fvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyapecinyykf
ssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcw
tydvenrpgfaavelrlrnyyydvvneg

SCOPe Domain Coordinates for d4pv0a_:

Click to download the PDB-style file with coordinates for d4pv0a_.
(The format of our PDB-style files is described here.)

Timeline for d4pv0a_: